ChemInform Abstract: Antiinflammatory 4,5-Diarylimidazoles as Selective Cyclooxygenase Inhibitors
| Autor: | Paul W. Collins, Richard M. Weier, Stealey Michael A, Thomas E. Barta |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | ChemInform. 30 |
| ISSN: | 1522-2667 0931-7597 |
| DOI: | 10.1002/chin.199917129 |
| Popis: | The synthesis and activity of a series of 4,5-diarylimidazole analogs are described. One analog had an IC50 of 80 nM, was 6750-selective against COX-1, and demonstrated in vivo potency in the mouse air pouch model. |
| Databáze: | OpenAIRE |
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