Abstract 085: Pediatric Dyslipidemia Is Associated With Higher Urinary Angiotensin Converting Enzyme Activity And Blood Pressure Values In A Brazilian Cohort
| Autor: | Nayara Azinheira Nobrega Cruz, Lilian Caroline G Oliveira, JOSE GERALDO MILL, Dulce E Casarini |
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| Rok vydání: | 2022 |
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| Zdroj: | Hypertension. 79 |
| ISSN: | 1524-4563 0194-911X |
| Popis: | Angiotensin converting enzyme (ACE) upregulation in adults contributes to cardiometabolic diseases including dyslipidemia and atherosclerosis. Objective: Investigate whether ACE activity is modulated in pediatric dyslipidemia. Methods: We evaluated anthropometric measurements, blood pressure and fasting lipid concentrations of 360 individuals (190 boys and 170 girls) aged from 6 to 19 year (mean 11.6). Categorization was done according to the levels of each lipoprotein (Total cholesterol (TC), triglycerides (TG), LDL-C, HDL-C, and non-HDL) into three groups: normolipidemic, borderline and dyslipidemic; reference values were according to American Academy of Pediatrics and Brazilian Pediatric Society. ACE activity in urine was measured with the substrates Z-FHL-OH and hippuryl-HL-OH. ACE activity ratio to infer N-domain activity was calculated (Z-FHL/h-HL). Results: Dyslipidemic levels of HDL-C, TG and LDL-C were observed in 23%, 9% and 3% of the participants, respectively. These clinical alterations were more frequent in obese children (Chi-square, p Conclusion: Pediatric hypertriglyceridemia, HDL-C deficiency and high LDL-C were related to higher urinary ACE activity (mainly N-domain). ACE modulation can contribute to higher risk of hypertension and other cardiometabolic alterations still in childhood and adolescence. Also, impairment in lipoprotein levels was associated with higher blood pressure values. |
| Databáze: | OpenAIRE |
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