Pantoprazole 20 mg is effective for relief of symptoms and healing of lesions in mild reflux oesophagitis

Autor:	F. Sielaff, A. Dettmer, R. Lühmann, R. Vogt, A. Schneider, R. Fischer
Rok vydání:	1998
Předmět:	medicine.medical_specialty education.field_of_study Hepatology Esophageal disease business.industry medicine.drug_class Population Gastroenterology Heartburn Proton-pump inhibitor medicine.disease Ranitidine Internal medicine medicine GERD Pharmacology (medical) medicine.symptom business education Esophagitis Pantoprazole medicine.drug
Zdroj:	Alimentary Pharmacology & Therapeutics. 12:865-872
ISSN:	0269-2813
DOI:	10.1046/j.1365-2036.1998.00381.x
Popis:	Aim: To investigate the efficacy of a low dose of pantoprazole, a gastric proton pump inhibitor, for the relief of symptoms and healing of lesions in mild gastro-oesophageal reflux disease (GERD), and to compare it with the efficacy of ranitidine. Methods: Patients with endoscopically established GERD (Stage I, Savary–Miller classification) were enrolled into a randomized, double-blind, parallel-group and multicentre study (intention-to-treat n = 209, age range 19–82 years). They were treated once daily with oral pantoprazole 20 mg or ranitidine 300 mg, for up to 8 weeks. End-point parameters included relief of symptoms (heartburn, acid regurgitation, pain on swallowing) and the healing of GERD lesions. Relief from symptoms was assessed after 2 and 4 weeks, and endoscopically confirmed healing of lesions after 4 and 8 weeks. Results: The proportion of patients reporting complete relief from symptoms after 2 weeks was greater in the pantoprazole than in the ranitidine group (69 vs. 48%, P
Databáze:	OpenAIRE
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