An evaluation of 6% hydroxyethyl starch 130/0.4 use in fluid therapy following coronary artery surgery

Autor: Hasan Alper Gündüz, Fatih Tanzer Serter, Cem Yorgancioğlu, Ahmet Baris Durukan, Halil İbrahim Uçar, Elif Durukan, Murat Tavlaşoğlu, Nevriye Salman
Rok vydání: 2013
Předmět:
Zdroj: Turkish Journal of Thoracic and Cardiovascular Surgery. 21:276-283
ISSN: 1301-5680
Popis: Amac: Bu calismada koroner arter baypas cerrahisi yapilan hastalarda %6 hidroksietil nisasta 130/0.4’un etkileri, siklikla kullanilan dengeli bir elektrolit solusyonu ile karsilastirildi. Ca­lis­ma­pla­ni:­Koroner arter baypas cerrahisi yapilan 157 hasta iki gruba randomize edildi. Ilk gruba %6 hidroksietil nisasta 130/0.4, ikinci gruba ise siklikla kullanilmakta olan dengeli bir elektrolit solusyonu verildi. Her iki solusyonun da ameliyat sonrasi sonuclar uzerine olan etkileri arastirildi. Bul gu lar: Yuze alti hidroksietil nisasta 130/0.4 ameliyat sonrasi kan kaybi ve kullanilan kan ve kan urunu miktarini artirmadi (p>0.05). Renal ve pulmoner fonksiyonlar uzerine olumsuz etkisi saptanmadi. Entubasyon zamani, yogun bakim kalis suresi ve ameliyat sonrasi hastane kalis suresi acisindan gruplar arasinda fark gorulmedi (p>0.05). Hidroksietil nisastanin ameliyat sonrasi atriyal fibrilasyon olusumu uzerine herhangi bir etkisi saptanmadi (p>0.05). So­nuc:­ Yuze alti hidroksietil nisasta 130/0.4 koroner baypas cerrahisi sonrasi sivi tedavisinde guvenli olarak kullanilabilir. Anah tar soz cuk ler: Kalp cerrahisi; kristalloid solusyonlar; hidroksietil nisasta. Background:­This study aims to compare the effects of 6% hydroxyethylstarch 130/0.4 with a commonly used balanced electrolyte solution in patients undergoing coronary artery bypass surgery. Methods: One hundred and fifty seven patients who underwent coronary artery bypass surgery were randomized into two groups. The first group received 6% hydroxyethyl starch 130/0.4, while the second group received a commonly used balanced electrolyte solution. The effects of both solutions on postoperative outcomes were studied. Results:­ Six percent hydroxyethyl starch 130/0.4 did not increase postoperative blood loss and the amount of blood and blood products (p>0.05). No adverse effect was observed on renal and pulmonary functions. Intubation time, intensive care unit stay and postoperative duration of hospital stay did not differ between the groups (p>0.05). Hydroxyethyl starch had no effect on the occurrence of postoperative atrial fibrillation (p>0.05). Conclusion:­Six percent hyroxyethyl starch 130/0.4 may be considered safe in fluid therapy following coronary bypass surgery.
Databáze: OpenAIRE