The functional neuroanatomy of verbal memory in Alzheimer’s disease: [18F]-Fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) correlates of recency and recognition memory
| Autor: | Adam M. Staffaroni, M. Mandelkern, Rebecca J. Melrose, David L. Sultzer, Dylan G. Harwood, Hannah Riskin-Jones, Lorraine P. Leskin |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.diagnostic_test
Recall 05 social sciences medicine.disease Verbal learning behavioral disciplines and activities 050105 experimental psychology Serial position effect 03 medical and health sciences Clinical Psychology 0302 clinical medicine Neurology Positron emission tomography medicine Dementia 0501 psychology and cognitive sciences Orbitofrontal cortex Neurology (clinical) Verbal memory Psychology Neuroscience 030217 neurology & neurosurgery Recognition memory |
| Zdroj: | Journal of Clinical and Experimental Neuropsychology. 39:682-693 |
| ISSN: | 1744-411X 1380-3395 |
| Popis: | Introduction: The objective of this study was to distinguish the functional neuroanatomy of verbal learning and recognition in Alzheimer’s disease (AD) using the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) Word Learning task. Method: In 81 Veterans diagnosed with dementia due to AD, we conducted a cluster-based correlation analysis to assess the relationships between recency and recognition memory scores from the CERAD Word Learning Task and cortical metabolic activity measured using [18F]-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET). Results: AD patients (Mini-Mental State Examination, MMSE mean = 20.2) performed significantly better on the recall of recency items during learning trials than of primacy and middle items. Recency memory was associated with cerebral metabolism in the left middle and inferior temporal gyri and left fusiform gyrus (p |
| Databáze: | OpenAIRE |
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