Synthesis of Porous Magnetic Hollow Silica Nanospheres for Nanomedicine Application
| Autor: | J. F. Chen, † and C. J. O'Connor, Weidong Zhou, Daniela Caruntu, W. Wu, Jisheng Zhou, A. Martin, M. H. Yu |
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| Rok vydání: | 2007 |
| Předmět: |
Packed bed
Materials science Composite number Nanoparticle Nanotechnology Surfaces Coatings and Films Electronic Optical and Magnetic Materials law.invention chemistry.chemical_compound General Energy chemistry Chemical engineering law Magnetic nanoparticles Nanomedicine Calcination Physical and Theoretical Chemistry Porosity Magnetite |
| Zdroj: | The Journal of Physical Chemistry C. 111:17473-17477 |
| ISSN: | 1932-7455 1932-7447 |
| Popis: | A porous magnetic hollow silica nanosphere (MHSN) is a new nanostructured drug carrier for increasing drug loading capability. Keeping the magnetic nanoparticles in the hollow core will limit the toxicity and degradation in a biosystem. In this paper, we report a synthesis of porous MHSNs by sol−gel method. CaCO3/Fe3O4 composite particles were first fabricated by embedding Fe3O4 nanoparticles into CaCO3 using the rotating packed bed (RPB) method. Tetraethoxysilane (TEOS) was then added as precursor to form a silica (SiO2) layer on the surface of CaCO3/Fe3O4 composite particles. Hexadecyltrimethylammonium bromide (CTAB) and octane act as second templates for the formation of porous silica shells. After removing the surfactants by calcination and etching away the CaCO3 particles, porous MHSNs with magnetite (Fe3O4) nanoparticles inside the cores were formed. The pore size can be tuned by adjusting the amount of the cationic surfactant absorbed on the surface of the composite particles to form self-assembled... |
| Databáze: | OpenAIRE |
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