Anti-adipocyte antibody response in patients with non-alcoholic fatty liver disease
| Autor: | Azza Karrar, Fanny Monge, Zobair M. Younossi, Zahra Younoszai, Elena Younossi, Li Zheng, Sneha Lingam, Lakshmi Alaparthi, Maria Stepanova, Khatera S. Malik, Sharon L. Hunt, Zachary Goodman |
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| Rok vydání: | 2015 |
| Předmět: |
Hepatology
biology business.industry Fatty liver Gastroenterology Autoantibody nutritional and metabolic diseases Odds ratio medicine.disease digestive system digestive system diseases Immunoglobulin G Pathogenesis Liver disease Immunoglobulin M Immunology biology.protein medicine Steatohepatitis business |
| Zdroj: | Journal of Gastroenterology and Hepatology. 30:900-908 |
| ISSN: | 0815-9319 |
| DOI: | 10.1111/jgh.12856 |
| Popis: | Background and Aim A significant number of autoantibodies have been reported in patients with non-alcoholic fatty liver disease (NAFLD) patients. In the present study, our aim was to assess the role of disease and cell-specific antibodies, namely anti-adipocyte antibodies (anti-AdAb) in patients with NAFLD and non-alcoholic steatohepatitis (NASH). Methods Flow cytometry was used to detect the presence of anti-AdAb (immunoglobulin M [IgM] and immunoglobulin G [IgG]) in sera from patients with biopsy-proven NAFLD (n = 98) and in controls (n = 49) without liver disease. Univariate and multivariate analysis was performed to draw associations between anti-AdAb IgM and IgG levels and the different clinical variables. Results Patients with NAFLD had significantly higher levels of anti-AdAb IgM and significantly lower levels of AdAb IgG when compared with controls (P = 0.002 and P |
| Databáze: | OpenAIRE |
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