Syntheses of reactive fluorescent stains derived from 5(2)-aryl-2(5)-(4-pyridyl)oxazoles and bifunctionally reactive linkers

Autor:	Joel M. Kauffman, Peter T. Litak
Rok vydání:	1994
Předmět:	Aryl Organic Chemistry Epoxide Combinatorial chemistry chemistry.chemical_compound Sulfonate chemistry Isothiocyanate Organic chemistry heterocyclic compounds Piperidine Fluorescein Maleimide Oxazole
Zdroj:	Journal of Heterocyclic Chemistry. 31:457-479
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570310236
Popis:	Several bifunctionally reactive linkers containing halide or sulfonate ester groups were prepared. The linkers were used to quaternize 5-(4-methoxyphenyl)-2-(4-pyridyl)oxazole and 2-(6-chromanyl)-5-(4-pyridyl)oxazole to produce fluorescent stains that contained a reactive group such as an isothiocyanate, an N-hydroxysuccinimidyl ester, a maleimide, or an oxirane. The stains were derivatized with either 1-propylamine, 1-propanethiol, or piperidine, as appropriate, to help in characterization. The stains may serve as more photostable alternatives to fluoresceins or coumarins.
Databáze:	OpenAIRE
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