| Popis: |
Artificial skin is a bilayer skin replacement system designed to regenerate dermal tissue. Prior to the commercial availability of artificial skin, surgically created wounds that cannot be closed by primary means (such as excising deep partial or full-thickness burns), had to be treated with autograft; a graft of the patient’s own skin harvested from a healthy donor site. This is because the dermal layer of skin cannot regenerate functional tissue spontaneously; instead, scar tissue forms. When applied surgically to a clean, excised wound bed, autograft becomes permanently engrafted, that is, it becomes permanently affixed to the underlying tissue and vascularized. However, autograft has serious drawbacks, including the creation of a donor wound, which has its own significant morbidity, and its unavailability in sufficient quantity in patients with large wounds. |
