3D amoeboid migration of a eukaryotic cell in a fiber matrix

Autor:	Donald L. Ly, Charles J. Lumsden
Rok vydání:	2009
Předmět:	Chemistry Cell Adhesion Matrix (biology) General Biochemistry Genetics and Molecular Biology Cell biology Extracellular matrix medicine.anatomical_structure Artificial Intelligence Cancer cell medicine Pseudopodia Wound healing Process (anatomy)
Zdroj:	Artificial Life and Robotics. 14:1-6
ISSN:	1614-7456 1433-5298
DOI:	10.1007/s10015-008-0708-0
Popis:	A basic event in amoeboid-type cell movement (ATCM) is extension of an exploratory cell protrusion called a pseudopod. ATCM of cells among the fibrous macromolecules of the extracellular matrix (ECM) is crucial to tissue development and wound healing, and a key process in immune response and cancer invasion. We studied ATCM by developing a computational model of pseudopod extension/retraction driving ECM sensing, cell-matrix adhesion, and cell translocation within the 3D ECM mesh. We were successful in producing a biomorphic ATCM motion cycle involving viscoelastic protrusion and attachment to ECM, cell body displacement, and cell detachment from old adhesion sites. The simulated trajectories were in general persistent random walks resembling ATCM patterns reported for patrolling immune cells and cancer cell invasion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::784d2383139b33629df3c7e259803914 https://doi.org/10.1007/s10015-008-0708-0 Zobrazit plný text záznamu Full text from SpringerLink