Symposium Summary
| Autor: | Luqi Pei, Stuart Cracknell, James D. Blanchard, Jeffrey S. Tepper, Philip J. Kuehl, Kristen J. Nikula |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Inhalation exposure
medicine.medical_specialty business.industry Inhalation Toxicology Context (language use) Respiratory physiology Toxicology 030226 pharmacology & pharmacy Pulmonary function testing 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Need to know Breathing medicine Dosimetry Intensive care medicine business |
| Zdroj: | International Journal of Toxicology. 35:376-392 |
| ISSN: | 1092-874X 1091-5818 |
| DOI: | 10.1177/1091581815624080 |
| Popis: | Developing inhaled drugs requires knowledge of lung anatomy, cell biology, respiratory physiology, particle physics, and some plumbing. Although dose makes the poison, in the context of an inhaled drug, the “dose” is not easily defined. This lack of clarity around dose poses issues and challenges in the design of inhalation toxicology programs. To better understand dose, the influence of ventilation is discussed as are the perturbations in pulmonary function observed with inhalation exposure that can affect dose. Methods for determining inhaled drug deposition to arrive at an estimate of lung dose are examined. Equally important to understanding dose are the techniques used to deliver aerosols to animals. With a better understanding of dose and inhalation exposure, species-specific histopathologic lesions, both common background and toxicologically significant lesions, are reviewed. Finally, insight into how regulators synthesize and evaluate these complex findings to assess clinical safety risks is presented. |
| Databáze: | OpenAIRE |
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