Selectivity and the Separation of Isomers of Low Molecular Weight Polystyrenes

Autor:	R. Andrew Shalliker, Gary R. Dennis, Michael J. Gray, Paul Wormell, Alan P. Sweeney
Rok vydání:	2004
Předmět:	Chromatography Clinical Biochemistry Analytical chemistry Pharmaceutical Science Reversed-phase chromatography Biochemistry Analytical Chemistry Hexane Solvent chemistry.chemical_compound chemistry Phase (matter) Methanol Solubility Acetonitrile Selectivity
Zdroj:	Journal of Liquid Chromatography & Related Technologies. 27:2905-2920
ISSN:	1520-572X 1082-6076
DOI:	10.1081/jlc-200030835
Popis:	The separation of diastereoisomers of polystyrene has been investigated on carbon‐clad zirconia (CCZ), C18, and diamond C18 stationary phases using eluents of widely different properties. Eluents were chosen according to their selectivity, solvent polarity index, and polymer solubility constants. Acetonitrile mobile phases in combination with CCZ produced the best diastereoisomer separations, however, when methanol was employed as the mobile phase, the separation profiles were very similar, except that retention was greatly increased. Retention and isomer separation decreased when isopropanol was employed. Surprisingly, some diastereoisomer separation was still apparent using the CCZ column and a 99% hexane/1% isopropanol mobile phase, although none was observed for the same solvent mixture on a C18 column. Indeed, significant diastereoisomer separation was only obtained on the C18 column‐using acetonitrile as the mobile phase, but the resolution was far inferior to that observed on the CCZ colum...
Databáze:	OpenAIRE
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