Determination of acetaminophen by electrochemical co-deposition of glutamic acid and gold nanoparticles
| Autor: | Gi Hun Seong, Cheng Ai Li, Minh Phuong Ngoc Bui, Kwi Nam Han, Xuan-Hung Pham |
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| Rok vydání: | 2012 |
| Předmět: |
Detection limit
Chemistry Inorganic chemistry Metals and Alloys Condensed Matter Physics Electrochemistry Ascorbic acid Surfaces Coatings and Films Electronic Optical and Magnetic Materials Electrochemical gas sensor Colloidal gold Electrode Materials Chemistry Differential pulse voltammetry Electrical and Electronic Engineering Cyclic voltammetry Instrumentation |
| Zdroj: | Sensors and Actuators B: Chemical. 174:318-324 |
| ISSN: | 0925-4005 |
| DOI: | 10.1016/j.snb.2012.08.012 |
| Popis: | We developed an electrochemical sensor to detect acetaminophen by electrochemically co-depositing glutamic acid and gold nanoparticles on a single-walled carbon nanotube film (AuNP-PGA/SWCNT). Cyclic voltammetry indicated that the electrochemical oxidation of acetaminophen at the AuNP-PGA/SWCNT film electrode involved a two-electron, one-proton process and was pH dependent. Different pulse voltammograms of acetaminophen oxidation on the AuNP-PGA/SWCNT film electrode yielded a well-defined oxidation peak at 360 mV in 0.1 M phosphate buffered saline buffer (pH 7.2) with linear calibration from 8.3 to 145.6 μM ( R 2 = 0.997). The detection limit was estimated to be 1.18 μM. The proposed sensor is stable and reproducible from 1.15 to 5.21% with a relative standard deviation of 3.56%. The AuNP-PGA/SWCNT film electrode was able to detect acetaminophen in the presence of interfering ascorbic acid; two well-defined oxidation peaks, one for ascorbic acid at 0.15 V and the other for acetaminophen at 0.39 V, were detected. Furthermore, the fabricated sensor accurately measured the amount of acetaminophen in pharmaceutical samples. Together, these results indicate that our AuNP-PGA/SWCNT film is a promising platform for accurate and reproducible detection of acetaminophen. |
| Databáze: | OpenAIRE |
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