| Popis: |
Dopamine (DA) inhibits excitatory synaptic transmission in the anterior cingulate cortex (ACC), a brain region involved in the sensory and affective processing of pain. However, DA modulation of inhibitory synaptic transmission in the ACC and its alteration of excitatory/inhibitory (E/I) balance remains relatively understudied. Using patch-clamp recordings, we demonstrate that DA inhibits γ-Aminobutyric acid subtype A (GABAA) receptor-mediated evoked inhibitory currents (eIPSCs) through postsynaptic D2 receptors. Recording excitatory and inhibitory currents from the same neuron yielded a heterogenous response dominated by GABAergic transmission. However, complete Freund’s adjuvant (CFA), a model of inflammatory pain, reduced the percentage of neurons showing synaptic inhibition by DA in the ACC. These results indicate that inflammatory pain induces changes in the interplay between DA signalling and inotropic transmission in the ACC of mice. |
