| Autor: |
Ross D. Brown, L. Barrow, Daniel Sze, Margaret Nelson, Maria Raitakari, Douglas E. Joshua, Belinda Pope, Warren Esdale, E. Yuen, John Gibson |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
British Journal of Haematology. 110:203-209 |
| ISSN: |
0007-1048 |
| DOI: |
10.1046/j.1365-2141.2000.02131.x |
| Popis: |
The presence of T-cell clones in peripheral blood has been previously shown to be associated with a survival advantage in patients with multiple myeloma and suggests that the expanded T-cell populations may be involved in an anti-tumour response. We studied the T-cell receptor (TCR) repertoire of 38 patients with myeloma to identify and characterize the expanded T-cell populations by flow cytometry. T-cell expansions were found in 79% of the patients. The expansions occurred randomly among the 21 variable regions of the TCR β chain (Vβ) studied, representing 62% of the V-β repertoire, and were stable during an 18-month follow-up. The phenotype of the expanded V-β populations was predominantly CD8+, CD57+, CD28− and perforin+, which differed significantly from the other non-expanded Vβ populations. The expression of the apoptosis markers Fas (CD95) and bcl-2 were similar between the expanded and non-expanded Vβ populations. In conclusion, expanded T-cell populations were frequent in patients with myeloma, they remained unchanged during follow-up and had phenotypic characteristics of cytotoxic T cells. These data add further support to the concept that the T-cell expansions may have an immunoregulatory role in myeloma. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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