A Newfangled Synthesis of Integrase Inhibitor Drug Substance Raltegravir Potassium

Autor:	Ramesh Babu Potluri, S. Venkat Rao, Vamsi Krishna Potluri
Rok vydání:	2019
Předmět:	Drug 010405 organic chemistry Chemistry media_common.quotation_subject Integrase inhibitor General Chemistry Pharmacology 010402 general chemistry 01 natural sciences 0104 chemical sciences media_common Raltegravir Potassium
Zdroj:	Asian Journal of Chemistry. 31:2618-2622
ISSN:	0975-427X 0970-7077
DOI:	10.14233/ajchem.2019.22246
Popis:	Raltegravir sodium synthesis was achieved from its one of the key starting materials with retro synthetic approach, in which without using its critical starting material chemically known as 5-methyl-1,3,4-oxadiazole-2-carbonyl chloride and which is more unstable during the synthesis of raltegravir potassium. Almost all the existed literatures commonly using this starting material in its synthesis even it is having a stability issue and hence to achieve a stable and economically viable synthesis. The current research describes a new route of synthesis by constructing an oxadiazole ring in a retro synthetic manner.
Databáze:	OpenAIRE
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