Pleural and systemic cytokine expression profiles in patients with lung cancer
| Autor: | Rudolf M. Huber, Marina Schaule, Amanda Tufman, Julia Stump, Pontus Mertsch, Sebastian Kobold, David Betz, Diego Kauffmann-Guerrero, Rosemarie Kiefl, Kathrin Kahnert |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Angiogenin Pleural effusion business.industry Lymphocyte medicine.medical_treatment Immunotherapy respiratory system medicine.disease Systemic inflammation Gastroenterology respiratory tract diseases medicine.anatomical_structure Cytokine Internal medicine medicine Malignant pleural effusion medicine.symptom business Lung cancer |
| Zdroj: | Lung Cancer. |
| Popis: | Introduction: Immunotherapy is of increasing relevance in NSCLC; however, the local and systemic regulation of the tumor/host interaction is not well understood. Cytokines regulate a number of processes in this interaction. Methods: In this cross sectional study we collected pleural effusion and serum from patients with lung cancer and controls and quantified 12 Cytokines (IL-22, IL-8, Angiogenin, MMP-9, CXCL-5, TFF3, IGF-1, TGF-s1, TGF-s2, IGFBP-3, IL-6, VEGF; selection of cytokines based on previous results) by specific ELISA Kits. We documented clinical markers of systemic inflammation including CRP, leucocyte- and lymphocyte counts. Lung cancer patients were compared to controls, and within each group local cytokine and systemic cytokine levels were compared. Results: 30 patients were included (19 lung cancer, 11 controls). IGF-1 showed higher expression in pleural fluid samples from patients with lung cancer compared to patients without lung cancer (p= 0.017). In patients with lung cancer, both VEGF and TGF-beta2 expression were higher in pleural fluid than in serum (p=0.001 and p= 0.011). The concentration of IL-22 in pleural fluid from lung cancer patients correlated with systemic leucocyte counts (spearman coefficient -0,47; p=0,04). Discussion: There are some significant differences in cytokine expression in pleural fluid from lung cancer patients compared with controls. In addition, systemic cytokine expression (in particular VEGFR and TGF-beta2) differs from expression in the pleural compartment in patients with lung cancer. These differences may be of diagnostic relevance and might offer targets for novel treatments of malignant pleural effusion in lung cancer. |
| Databáze: | OpenAIRE |
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