| Autor: |
A.S. Craig, A.E. Goodship, David A.D. Parry, I.F. Williams, I.A. Silver, J. Shah |
| Rok vydání: |
1985 |
| Předmět: |
|
| Zdroj: |
International Journal of Biological Macromolecules. 7:275-282 |
| ISSN: |
0141-8130 |
| DOI: |
10.1016/0141-8130(85)90025-x |
| Popis: |
Normal tendon comprises coaxially aligned bundles of crimped collagen fibres each of which possesses a fibrillar substructure. In acute traumatic injury this level of organization is disrupted and the mechanical function of the tendon impaired. During repair, a degree of recovery of the fibrillar structure takes place. In this tudy we have assessed the re-establishment of tendon organization after injury on the basis of the collagen fibril diameter distribution and the collagen crimp parameters. Crimp became undetectable following injury but one month later was present throughout the tissue. At this time the periodicity was greatly reduced by comparison with that of the normal tendon and normal values were not re-established within 14 months following injury. Collagen fibril diameters remained abnormally small over this same period of time. In particular, fibrils of diameters in excess of 100 nm, commonly found in normal and contralateral tendons, were totally absent from the observed distributions in the healing tendons. Such large diameter fibrils often account for as much as 50% of the total mass of collagen present in the uninjured tissue. Thus the mechanical properties of the healing tendon may remain significantly different from those of normal tendon for a minimum time of 14 months after injury. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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