pH-sensitive and bioadhesive poly(β-amino ester)–poly(ethylene glycol)–poly(β-amino ester) triblock copolymer hydrogels with potential for drug delivery in oral mucosal surfaces

Autor:	Cong Truc Huynh, Doo Sung Lee, Minh Khanh Nguyen
Rok vydání:	2009
Předmět:	chemistry.chemical_classification Materials science Polymers and Plastics Bioadhesive Organic Chemistry Polymer Gel permeation chromatography chemistry.chemical_compound chemistry Self-healing hydrogels Polymer chemistry Materials Chemistry Copolymer Drug carrier Ethylene glycol Tetrahydrofuran
Zdroj:	Polymer. 50:5205-5210
ISSN:	0032-3861
Popis:	A series of novel pH-sensitive triblock copolymers composed of poly(β-amino ester)–poly(ethylene glycol)–poly(β-amino ester) (PAE–PEG–PAE) were synthesized by conjugating poly(β-amino ester) to poly(ethylene glycol). The resulting polymers were characterized by 1H and 13C NMR in CDCl3 and gel permeation chromatography in tetrahydrofuran. The concentrated polymer solutions (30 wt%) exhibited a gel-to-sol transition in the pH range 6.4–7.8. The gel window spanned physiological conditions (37 °C, pH 7.4). After injection into a rat, the copolymer solution (30 wt%) changed to a gel in a short time. This copolymer hydrogel showed bioadhesive properties and in vitro release of lidocaine was controllable.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::782b5448c7fda1ecba313e6248635fef https://doi.org/10.1016/j.polymer.2009.09.040 Zobrazit plný text záznamu Full Text from ScienceDirect