The spleen and skin wound healing inXenopusadults
| Autor: | Antonella Franchini, Evelina Bertolotti, Annalaura Della Rocca |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
White pulp Skin repair Pathology medicine.medical_specialty Germinal center Spleen Biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Lymphatic system Reticular cell medicine Red pulp Animal Science and Zoology Periarteriolar lymphoid sheaths 030215 immunology Developmental Biology |
| Zdroj: | Journal of Morphology. 277:888-895 |
| ISSN: | 0362-2525 |
| Popis: | In most vertebrates, the regenerative capacity to restore lost/damage tissues to original structure and functionality decreases at some time during ontogenesis. To evaluate the role of the acquired immunity in the decline of regenerative potential, we examined the cellular responses elicited in the spleen during skin repair in Xenopus adults. Modifications in the architecture were found to be induced and were remarkable 14 days postinjury when the spleen increased significantly in size. In white pulp, the periarteriolar lymphoid sheaths were associated with follicles having central light zones, morphologically similar to germinal centers. With the progress of healing, pigment-containing cells were seen to accumulate in both white and red pulp regions. Moreover, compared to controls, the cells immunoreactive to anti-cytokines (TNF-α, TGF-β1) and -iNOS increased from the first days after wounding. The 14th day, the positive cells formed a dense network of reticular cells in central regions of lymphoid follicles and more frequent reactive leukocytes were detected within the red pulp. A higher number of lymphoid cells immunostained with anti-CD3e were also observed in the perifollicular zone. The results suggest that the spleen of adult frogs is involved in skin wound healing with the expansion of lymphoid compartments. J. Morphol. 277:888-895, 2016. © 2016 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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