Biological Aging and Longevity: Underlying Mechanisms and Potential Intervention Strategies

Autor:	George R. Martin, George T. Baker
Rok vydání:	1994
Předmět:	Senescence Gerontology Physiological function Life span Smoking habit media_common.quotation_subject Rehabilitation Longevity Physical Therapy Sports Therapy and Rehabilitation Biology Lifestyle factors Intervention (counseling) Geriatrics and Gerontology media_common
Zdroj:	Journal of Aging and Physical Activity. 2:304-328
ISSN:	1543-267X 1063-8652
DOI:	10.1123/japa.2.4.304
Popis:	Aging is characterized by numerous physical, physiological, biochemical, and molecular changes. The rates at which aging processes occur are highly variable among individuals and are thought to be governed by both environmental and genetic factors. Lifestyle factors such as exercise, dietary, and smoking habits have been demonstrated to alter many of the changes usually associated with human aging. However, at present caloric restriction is the only experimental paradigm that has consistently been demonstrated in animal models to extend not only physiological vigor but also life span. The positive effects of exercise on physiological fitness and the reduction in the risks of certain diseases have been well documented. However, its effects on life span are not as clear. This article explores some of the basic mechanisms thought to be involved causally in the processes of aging, and outlines current and potential interventive strategies to retard or ameliorate the rates of decline in physiological function with advancing age.
Databáze:	OpenAIRE
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