[14C]Ceftiofur Sodium Absorption, Distribution, Metabolism, and Excretion in Sheep following Intramuscular Injections

Autor:	Kenneth L. Davison, Cathy L. Gatchell, Tom J. Vidmar, Thomas S. Arnold, Rex E. Hornish, Evan B. Smith, Maria G. Beconi-Barker, Gregory A. Hoffman, Arthur L. Craigmill, Terry J. Gilbertson
Rok vydání:	1995
Předmět:	medicine.medical_specialty Chemistry Metabolite Albumin General Chemistry Urine Excretion chemistry.chemical_compound Endocrinology Pharmacokinetics Internal medicine Blood plasma medicine General Agricultural and Biological Sciences Ceftiofur Feces
Zdroj:	Journal of Agricultural and Food Chemistry. 43:1589-1597
ISSN:	1520-5118 0021-8561
Popis:	Six Columbia and mixed-breed sheep (three rams and three females, 33-44 kg) were euthanatized 12 h after the last of 5 intramuscular doses at 2.2 mg of [ 14 C]ceftiofur sodium/kg of body weight. Total dose accountability was 103.5 ± 4.5% : 92.55 ± 4.10% in urine, 6.53 ± 0.85% in feces, 2.40 ± 0.14% in the carcass, and 0.69 ± 0.32% in the intestinal tract. Kidneys were the tissues with highest residue concentration (9.016 ± 1.153 μg/g, 0.29% of the dose). Most residues found in kidney and liver were associated with macromolecules (95.7% and 90.5%, respectively). Of the free residues, all corresponded to polar metabolites devoid of the β-lactam ring necessary for biological activity. Desfuroylceftiofur (DFC)-dimer was the most abundant metabolite (47.58%) found in urine. Polar metabolites devoid of a β-lactam ring comprised 38.5% of the total residues. In plasma, DFC was conjugated to albumin. Free residues containing an intact β-lactam ring were not found. [ 14 C]-Ceftiofur itself was never found in the excreta or plasma or as a tissue residue.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7825b87c44d013b47654812d86304601 https://doi.org/10.1021/jf00054a033 Zobrazit plný text záznamu