| Popis: |
In this review, Lawrence Sellin describes the botulinal neurotoxins which occur as seven immunologically distinct types A–G and may bind to a ‘proteoglycan component' on the extracellular face of the nerve terminal membrane. Following binding the toxin is internalized, probably via the membrane/vesicle recycling process, and blocks some step after membrane depolarization and Ca 2+ entry, affecting Ca 2+ -dependent synaptic vesicle exocytosis. The exact mechanism is unknown, but possible substrates for BoTx including Synapsin 1, the system for cAMP-dependent phosphorylation, Ca 2+ /calmodulin dependent protein kinases or those mechanisms responsible for mobilization and sequestration of Ca 2+ are discussed. |
