Palladium-catalyzed convenient one-pot synthesis of multi-substituted 2-pyrones via transesterification and alkenylation of enynoates

Autor:	Devesh M. Sawant, Ram T. Pardasani, Kandasamy Gopal, Ramdas S. Pathare, Shivani Sharma
Rok vydání:	2017
Předmět:	Reaction conditions 010405 organic chemistry Ligand Organic Chemistry One-pot synthesis chemistry.chemical_element Transesterification 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Catalysis chemistry Drug Discovery Organic chemistry Palladium
Zdroj:	Tetrahedron Letters. 58:1387-1389
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2017.02.060
Popis:	An efficient one-pot protocol for the synthesis of multi-substituted 2-pyrone derivatives from internal alkynes and unactivated alkenes is reported. The methodology involves difunctionalization of internal alkynes by using Pd(II) as a catalyst alongwith X-Phos as ligand via 6-endo transesterification and subsequent alkenylation pathway. Notable features include simple and easily available starting materials, including a range of unactivated alkenes, reduced synthetic steps and mild reaction conditions with high efficiency.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::78240df95d384394573f37690bdd317d https://doi.org/10.1016/j.tetlet.2017.02.060 Zobrazit plný text záznamu Full Text from ScienceDirect