Synthesis and antifungal properties of arginine-containing hemin derivatives

Autor:	V. G. Arzumanyan, N. V. Groza, S. A. Okorochenkov, V. E. Nebolsin, G. A. Zheltukhina
Rok vydání:	2011
Předmět:	chemistry.chemical_classification Cryptococcus neoformans Arginine biology Chemistry Organic Chemistry Peptide Fungus biology.organism_classification In vitro Microbiology Fungicide chemistry.chemical_compound Biochemistry General Pharmacology Toxicology and Pharmaceutics Candida albicans Hemin
Zdroj:	Medicinal Chemistry Research. 21:3876-3884
ISSN:	1554-8120 1054-2523
DOI:	10.1007/s00044-011-9928-2
Popis:	Due to a steadily increasing number of clinical isolates of microscopic fungi that show resistance to conventionally administered antimycotics, the specialists involved have constantly been searching for novel fungicidal agents among various classes of chemical compounds. The present study was aimed at synthesizing and assessing the activity of arginine-containing hemin derivatives against strains of Candida albicans and Cryptococcus neoformans insensitive to commonly used antifungal agents. A hemin conjugate with a branched arginine-containing peptide was shown to exhibit in vitro fungicidal activity at a concentration of 25 μM and inhibit the growth of the yeast-like fungus Candida albicans at concentrations as low as 12.5 μM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7821e00e029564e5019d014855dda366 https://doi.org/10.1007/s00044-011-9928-2 Zobrazit plný text záznamu Full text from SpringerLink