| Autor: |
A. D. Sadovnick, M. E. Irwin, P. A. Baird, B. L. Beattie, P. M. Conneally |
| Rok vydání: |
1989 |
| Předmět: |
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| Zdroj: |
Genetic Epidemiology. 6:633-643 |
| ISSN: |
0741-0395 |
| DOI: |
10.1002/gepi.1370060508 |
| Popis: |
All patients attending the Clinic for Alzheimer Disease and Related Disorders have detailed family histories taken by a geneticist. To date, genetic histories are available for 446 consecutive, unrelated individuals. Of these, 151 (33.9%) are diagnosed as having “probable” (N = 141) or “autopsy-confirmed“ (N = 10) Alzheimer disease according to recognized criteria. This data base represents a relatively unselected population with respect to more than one person in the family having dementia. Seventy-one of these 151 index cases (47.0%) have a positive family history of dementia, of which 8 (5.3%) may represent the familial (autosomal dominant) form of Alzheimer disease (FAD). Age-corrected empiric recurrence risks for Alzheimer disease/dementia were calculated for first-degree relatives of these 15 1 index cases using the Kaplan-Meier lifetable method. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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