Bulbiferates A and B: Antibacterial Acetamidohydroxybenzoates from a Marine Proteobacterium, Microbulbifer sp
| Autor: | Doug R. Braun, Dinith R Jayanetti, Tim S. Bugni, Kenneth J. Barns, Scott R. Rajski |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
biology 010405 organic chemistry Chemistry Stereochemistry Organic Chemistry Pharmaceutical Science Ecteinascidia turbinata medicine.disease_cause biology.organism_classification 01 natural sciences Microbulbifer sp 0104 chemical sciences Analytical Chemistry Tunicate 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Staphylococcus aureus Drug Discovery medicine Molecular Medicine Structure–activity relationship Antibacterial activity Escherichia coli Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Journal of Natural Products. 82:1930-1934 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.9b00312 |
| Popis: | Here we report the discovery of two new 3-acetamido-4-hydroxybenzoate esters, bulbiferates A (1) and B (2), isolated from Microbulbifer sp. cultivated from the marine tunicate Ecteinascidia turbinata. The structures of 1 and 2 were determined by analysis of 2D NMR and MS data. Additionally, three synthetic analogues (3-5), differing in ester sizes/lengths, were prepared for the purposes of evaluating potential structure-activity relationships; no clear correlations tying ester lengths to activity were evident. Bulbiferates A (1) and B (2) demonstrated antibacterial activity against both Escherichia coli (E. coli) and methicillin-sensitive Staphylococcus aureus (MSSA), whereas the synthetic analogues 3 and 4 displayed activity only against MSSA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|