Diagnostic de l’aspergillose bronchopulmonaire invasive : valeur du dosage du galactomannane dans le lavage bronchoalvéolaire de patients immunodéprimés
| Autor: | André Paugam, Agathe Lebuisson, Jean Dupouy-Camet, Marie-Thérèse Baixench |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test business.industry Direct examination Respiratory disease General Medicine Neutropenia medicine.disease Aspergillosis Gastroenterology Galactomannan chemistry.chemical_compound Bronchoalveolar lavage chemistry Internal medicine Immunopathology medicine skin and connective tissue diseases business Mycosis |
| Zdroj: | Pathologie Biologie. 58:100-103 |
| ISSN: | 0369-8114 |
| DOI: | 10.1016/j.patbio.2009.07.011 |
| Popis: | Invasive pulmonary aspergillosis (IPA) is an emerging disease associated with high mortality. The diagnosis is difficult, based on a combination of elements that are clinical, radiological and biological. For early detection of cases of IPA, during 25 months, we have systematically carried out on the LBA (N=355) of immunocompromised patients (N=313) a determination of Aspergillus galactomannan (GM) by ELISA (PlateliaAspergillus, BioRad). We observed 14 cases of probable API. The sensitivity of GM compared to direct examination (DE) and culture is, respectively, 64% versus 29% and 57%. The determination of GM is definitely more sensitive than the ED. Excellent specificity (98%) allows its implementation as a screening test in patients at risk. |
| Databáze: | OpenAIRE |
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