P48. Possible laboratory markers and anthropometric women with preeclampsia – Preliminary results

Autor: Diego Gomes Ferreira, Sérgio Floriano de Toledo, Patricia De Fatima Lopes De Andrade, Rogério Gomes dos Reis Guidoni, Leda Ferraz, Ana Paula de Almeida Righi, Maria Renata Lopes Natale Poltronieri, Francisco Lazaro Pereira de Sousa, Stephany Risnic Chvaicer, Natine Fuzihara Rosa, Claudia Valeria Chagas de Siqueira, Vivian Macedo Gomes Marçal
Rok vydání: 2015
Předmět:
Zdroj: Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health. 5:248-249
ISSN: 2210-7789
DOI: 10.1016/j.preghy.2015.07.101
Popis: Introduction Preeclampsia (PE) affects 5–8% of pregnant women, it is a multi-systemic damage which obesity is a predisposing factor and may be recognized by anthropometric measurements. The increased adiposity results in tissue necrosis and release of fatty acids, promoting metabolic changes known as lipotoxicity that causes endothelial damage. This immune disorder causes: vascular reactivity, vasospasm, alterations in capillary permeability and coagulation system. Resulting in anatomical/functional damage such as brain, cardio-pulmonary, renal, hepatic, hematological and utero-placental. This research project is part of a line of research that will assess the long-term values of the selected indicators in the remote postpartum period, thus seeking to observe the behavior of these effectors in the mother's body. Objective To evaluate possible laboratory and anthropometric markers in selected mothers with PE in the immediate postpartum compared to women without this complication. Methods Case-control study developed at the Hospital Guilherme Alvaro, Santos/Brazil. Blood samples and anthropometric data from 15 mothers were collected in the period from January to May/2015 in the immediate postpartum and analyzed selected laboratory and nutritional markers, possibly related to PE. Case group: women with PE according to the NHBPEP (2000). Control group: women with vaginal birth and newborn full-term, without hypertension and other comorbidities. Variables analyzed: maternal age, gestational age at birth, body mass index (BMI), neck, arm and abdominal circumferences, total cholesterol, HDL (high density lipoprotein), LDL (low-density lipoprotein), VLDL (very low- density lipoprotein), triglycerides, fasting glucose and insulin levels to calculate HOMA-IR index, C-reactive protein. Exclusion terms: collagen disease, smoking, twin pregnancy and fetal malformations. Results The total of 15 blood samples (09 – study group and 06 – control group). Conclusion This study showed that potential markers lipotoxicity and anthropometric data can relate to the PE, possibly indicating probable risk factors, contributing to the understanding of certain clinical expressions and possibly correlate with prognostic factors. More studies are needed to expand the preliminary information of the present study.
Databáze: OpenAIRE
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