| Autor: |
Ewan Forrest, Christine Toka, Jeremiah Sim |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Posters. |
| DOI: |
10.1136/gutjnl-2020-bsgcampus.263 |
| Popis: |
Introduction The development of acute kidney injury (AKI) in cirrhosis is associated with a poor outcome. Patidar et al, 2018 proposed the fractional excretion of urea (FeUrea) to distinguish pre-renal and hepatorenal syndrome from other causes of AKI in cirrhosis. However its prognostic significance out with AKI is unknown. Aim To assess the associations of FeUrea with liver and renal function and survival in patients with cirrhosis. Methods Patients with cirrhosis whose urine electrolytes had been assessed in the Gastroenterology wards at Glasgow Royal Infirmary between January 2016 and August 2019 were identified retrospectively. Contemporaneous blood tests were recorded. For outcome assessment the earliest urine electrolyte sample was recorded and subsequent samples within 90 days excluded. Pearson coefficient (r) was calculated for correlation. Cox proportional-hazards regression was used for multivariate analysis of variables related to outcome, and Kaplan-Meier analysis for survival analysis. Results In total 265 samples were analysed from 157 individuals. FeUrea correlated with markers of inflammation (CRP: r=-0.297; p 33.4% respectively (p=0.006). On multivariate analysis albumin (p=0.0002), bilirubin (p=0.04), creatinine (p=0.01), FeUrea (p=0.0001) and white cell count (WCC: p=0.02) independently predicted 28-day survival but only FeUrea (p=0.04) and WCC (p=0.02) predicted 90-day survival. MELD and presence of AKI were not independently related to outcome. Conclusion FeUrea was associated with markers of inflammation and liver dysfunction in patients with cirrhosis. FeUrea was predictive of survival independently of MELD and AKI. The categorisation of patients by FeUrea identified those with a poor 90-day outcome. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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