Ultrasound and the Blood-Brain Barrier
| Autor: | James T. Patrick, Stephen A. Goss, Kris A. Dines, Robert F. Heimburger, Jeffrey L. Clendenon, Mark N. Nolting, Michael A. Rea |
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| Rok vydání: | 1990 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry medicine.medical_treatment Ultrasound Caudate nucleus Blood–brain barrier High-intensity focused ultrasound Lesion White matter chemistry.chemical_compound medicine.anatomical_structure chemistry Stereotaxic technique Medicine medicine.symptom business Evans Blue |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9781468457681 |
| Popis: | High intensity focused ultrasound was employed to modify the permeability of the normal feline and canine blood-brain barrier (BBB) to a circulating vial dye — Evans blue (EB). The threshold doses (W sec/cm2) for focally increasing the permeability of the BBB in white matter (WM) and gray matter (GM) were as follows: internal capsule (WM) — 340 to 680; thalamus (GM) — approximately 1326; and caudate nucleus (GM) — 2284 to 2952. In the presence of supralesioning doses of ultrasound, the cross sectional area occupied by the EB was consistently greater than that of the attendant nonhemorrhagic lesion — thus suggesting that BBB changes may be inducible at sublesioning doses. These findings, in conjunction with those of others, suggest that high intensity focused ultrasound may have a role in the treatment of brain tumors based on cell destruction by two mechanisms: (a) direct, by the ultrasound and (b) indirect, by ari antineoplastic agent which is delivered via an ultrasonically modified BBB. |
| Databáze: | OpenAIRE |
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