Safety vs Efficiency in the Development of a High-Energy Compound

Autor:	David R. Bill, Ruggeri Sally G, Weston Neil Philip, Lulin Wei, Michael J. Castaldi, Tim L. Houck, Dennis E. Bourassa, David H. Brown Ripin
Rok vydání:	2003
Předmět:	chemistry.chemical_compound Materials science chemistry Organic Chemistry Moiety Oxadiazole Physical and Theoretical Chemistry Combinatorial chemistry Decomposition Energy (signal processing)
Zdroj:	Organic Process Research & Development. 7:1043-1047
ISSN:	1520-586X 1083-6160
Popis:	A scalable route to 5-(2-carboxy-pyridin-2-yloxy)-benz[1,2,5]oxadiazole (3) is demonstrated. The synthesis was designed to minimize potential safety issues with a previously practiced route and, in particular, to avoid the handling of 5-hydroxybenzofurazan, which was found to decompose with a large energy release at relatively low temperatures. The new route builds the benzofurazan moiety onto a nicotinonitrile core to avoid high-energy intermediates with low onset temperatures of decomposition.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::77f0693de107269ce09f9fe58141bb38 https://doi.org/10.1021/op0341059 Zobrazit plný text záznamu