The mineralization, drug release and in vivo bone defect repair properties of calcium phosphates/PLA modified tantalum scaffolds
| Autor: | Zhou Rong, Qirong Qian, Hai-Jian Ni, Feng Chen, Junjian Liu, Qiwei Fu, Ning Liu, Peng Jinhui, Shao Jiahua, Chen Shu |
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| Rok vydání: | 2020 |
| Předmět: |
Biocompatibility
General Chemical Engineering chemistry.chemical_element macromolecular substances 02 engineering and technology Calcium 010402 general chemistry 01 natural sciences Mineralization (biology) stomatognathic system In vivo Amorphous calcium phosphate Bovine serum albumin chemistry.chemical_classification biology General Chemistry Adhesion Polymer respiratory system equipment and supplies 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Chemical engineering biology.protein lipids (amino acids peptides and proteins) 0210 nano-technology |
| Zdroj: | RSC Advances. 10:7708-7717 |
| ISSN: | 2046-2069 |
| Popis: | Calcium phosphate based biomaterials have been widely studied in biomedical areas. Herein, amorphous calcium phosphate (ACP) nanospheres and hydroxyapatite (HA) nanorods were separately prepared and used for coating tantalum (Ta) scaffolds with a polymer of polylactide (PLA). We have found that different crystal phases of calcium phosphate coated on Ta scaffolds displayed different effects on the surface morphologies, mineralization and bovine serum albumin (BSA) release. The ACP-PLA and HA-PLA coated on Ta scaffold were more favorable for in vitro mineralization than bare and PLA coated Ta scaffolds, and resulted in a highly hydrophilic surfaces. Meanwhile, the osteoblast-like cells (MG63) showed favorable properties of adhesion and spreading on both ACP-PLA and HA-PLA coated Ta scaffolds. The ACP-PLA and HA-PLA coated Ta scaffolds showed a high biocompatibility and potential applications for in vivo bone defect repair. |
| Databáze: | OpenAIRE |
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