Enzymatic Transformations; 61. Preparation of Enantiopure Trifluoromethyl-Substituted Aromatic Epoxides and Vicinal Diols using theAspergillus niger Epoxide Hydrolase-Catalysed Resolution

Autor:	Fabien Barbirato, Alain Archelas, Roland Furstoss, Justine Deregnaucourt, Jean-Marc Paris
Rok vydání:	2006
Předmět:	Trifluoromethyl biology Stereochemistry Aspergillus niger Absolute configuration Substrate (chemistry) General Chemistry biology.organism_classification Kinetic resolution Enzyme catalysis chemistry.chemical_compound Enantiopure drug chemistry Organic chemistry Epoxide hydrolase
Zdroj:	Advanced Synthesis & Catalysis. 348:1165-1169
ISSN:	1615-4169 1615-4150
Popis:	The resolution of eight differently substituted trifluoromethylstyrene oxide derivatives was explored using the Aspergillus niger epoxide hydrolase. The obtained results indicate that all (but one) epoxides were efficiently processed by this enzyme, under very mild experimental conditions. The specific activity and the enantioselectivity of the enzyme against each substrate were determined. Circular dichroism analysis was also performed, allowing us to establish the absolute configuration of the products.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::77ed018c237c5d24a9bac663d338c711 https://doi.org/10.1002/adsc.200606061 Zobrazit plný text záznamu Plný text