The effects of radiation on cognative function in patients with low-grade glioma
| Autor: | B.P. O’Neill, R.P. Dinapoli, R.M. Arusell, T.L. Cascino, Edward G. Shaw, C.A. Brown, N.L. Iturria, J.C. Buckner, J.R. O’Fallon, P.D. Brown |
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| Rok vydání: | 2001 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Radiation Adult patients business.industry medicine.medical_treatment Cognition Physical function Radiation therapy Neurologic function Internal medicine Medicine Radiology Nuclear Medicine and imaging In patient Low-Grade Glioma Effects of sleep deprivation on cognitive performance business |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 51:135 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/s0360-3016(01)02069-7 |
| Popis: | Materials and Methods: We analyzed cognitive performance data collected in a prospective intergroup trial (Proc ASCO 17:1545, 1998) which randomized 203 eligible/analyzable adult patients with supratentorial low-grade gliomas to low-dose (50.4 Gy/28 fractions) versus high-dose (64.8 Gy/36 fractions) localized radiation therapy. Median follow-up is 7.4 years in the 101 patients still alive. Folstein mini-mental status exam (MMSE) scores and neurologic function scores (NFS) recorded at baseline and at each study evaluation were analyzed to assess cognitive and physical function over time. A loss or gain of greater than 3 points in MMSE was considered clinically significant. |
| Databáze: | OpenAIRE |
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