Antiplasmodial activity of quinine-zinc complex and chloroquine: A comparative in vitro assessment

Autor:	Olubanke Olujoke Ogunlana, O. G. Ademowo, Oluseyi Ebenezer Ogunlana
Rok vydání:	2012
Předmět:	Pharmacology Quinine Pharmaceutical Science chemistry.chemical_element Plasmodium falciparum Zinc Drug resistance Chloroquine diphosphate Biology biology.organism_classification medicine.disease In vitro chemistry Chloroquine parasitic diseases medicine Malaria medicine.drug
Zdroj:	African Journal of Pharmacy and Pharmacology. 6
ISSN:	1996-0816
DOI:	10.5897/ajpp11.482
Popis:	The evolving and complicating drug resistance exhibited by strains of Plasmodium falciparum to existing antimalarials like chloroquine and quinine (which are relatively more affordable than recent drugs) and advances in metal-drug complex research instigated this work. The antiplasmodial activity of the Quinine-Zinc complex (QZ) synthesized by a modification of the method of Singla and Wadhwa was assessed relative to that of Chloroquine diphosphate (C) in vitro. Measurement of antiplasmodial activity was carried out based on the inhibition of parasite growth measured by the inhibition of schizont formation in freshly collected infected blood samples from malaria patients. A comparative analysis of the antiplasmodial activity of QZ against C showed that its antiplasmodial activity was significantly better than that of C (p < 0.05). The result of this study suggests that the QZ could have a better therapeutic activity against malaria than C.
Databáze:	OpenAIRE
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