Anticancer activity studies of some cyclic benzimidazole derivatives

Autor:	Ali El-Shekeil, Abeer Obeid, Sama Al-Aghbari
Rok vydání:	2012
Předmět:	HeLa Benzimidazole chemistry.chemical_compound Schiff base chemistry biology Stereochemistry Proton NMR Methylene biology.organism_classification Cytotoxicity In vitro Malononitrile
Zdroj:	European Journal of Chemistry. 3:356-358
ISSN:	2153-2257 2153-2249
DOI:	10.5155/eurjchem.3.3.356-358.621
Popis:	New benzimidazole derivatives, namely, ( N -(4-methoxyphenyl)methylene]-1H-benzimidazol-2-amine (2a), ( N -(3,4-dimethoxyphenyl)methylene]-1 H -benzimidazol-2-amine (2b), and ( N -(3,4,5-trimethoxyphenyl)methylene]-1 H -benzimidazol-2-amine (2c) were synthesized by reaction of a Schiff base with malononitrile in absolute ethanol. Structures of compounds have been confirmed by IR, 1 H NMR and elemental analysis. Compounds 2a-c were screened for their in vitro anticancer potential using HeLa and PC3 cells. All compounds showed limited cytotoxicity except compound 2a that showed a moderate cytotoxic effect towards HeLa cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::77be6bf2bb34b0a2b760c74a63c657bb https://doi.org/10.5155/eurjchem.3.3.356-358.621 Zobrazit plný text záznamu