Discussion on 'Second-Guessing Clinical Trial Designs' by Jonathan J. Shuster and Myron N. Chang

Autor:	Nancy L. Geller
Rok vydání:	2008
Předmět:	Statistics and Probability Clinical trial Software Operations research Order (business) Complete information business.industry Modeling and Simulation Group sequential business Safety monitoring Mathematics
Zdroj:	Sequential Analysis. 27:41-45
ISSN:	1532-4176 0747-4946
DOI:	10.1080/07474940701801879
Popis:	While one may impose the group sequential design of one's choice on a completed trial in order to “second-guess” if a trial could have stopped early for either efficacy or futility, such calculations do not consider the mind-set of either those conducting the trial or the data and safety monitoring committee that reviewed the accumulating data. It is thus easy to come to questionable conclusions because of incomplete information. The optimal four-stage designs are interesting, but would be more useful if unequal look times were incorporated and software were made available.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::77be077a4cc6a46afe1e79fb9bd7de8e https://doi.org/10.1080/07474940701801879 Zobrazit plný text záznamu