Ketone bodies mediate antiseizure effects through mitochondrial permeability transition

Autor:	Jong M. Rho, Kristina A. Simeone, Patrick G. Sullivan, Do Young Kim, Jignesh D. Pandya, Timothy A. Simeone, Julianne Wilke, Younghee Ahn, James W. Geddes
Rok vydání:	2015
Předmět:	Neurology Biochemistry Mitochondrial permeability transition pore Chemistry Mechanism (biology) medicine.medical_treatment Seizure control Ketone bodies medicine Neurology (clinical) Neuroprotection Beta oxidation Ketogenic diet
Zdroj:	Annals of Neurology. 78:77-87
ISSN:	0364-5134
DOI:	10.1002/ana.24424
Popis:	Objective Ketone bodies (KB) are products of fatty acid oxidation and serve as essential fuels during fasting or treatment with the high-fat anti-seizure ketogenic diet (KD). Despite growing evidence that KB exert broad neuroprotective effects, their role in seizure control has not been firmly demonstrated. The major goal of this study was to demonstrate the direct anti-seizure effects of KB and to identify an underlying target mechanism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::77b78dd1a5eec574f47ac93fba21a76e https://doi.org/10.1002/ana.24424 Zobrazit plný text záznamu Plný text