Sulfamic acid-catalyzed multicomponent synthesis of 7-phenyl-7,12 dihydrobenzo(h)pyrido[2,3-b]naphthydrin-6(5H)-one derivatives: a green avenue

Autor:	Reshma B. Patil, D. R. Chandam, Sunetra J. Jadhav, Ajinkya A. Patravale, Madhukar B. Deshmukh, Digambar R. Kumbhar
Rok vydání:	2016
Předmět:	010405 organic chemistry Condensation General Chemistry 010402 general chemistry Combinatorial synthesis 01 natural sciences 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Atom economy Pyridine Sulfamic acid Organic chemistry
Zdroj:	Research on Chemical Intermediates. 43:2529-2543
ISSN:	1568-5675 0922-6168
Popis:	A series of novel 7-phenyl-7,12-dihydrobenzo(h)pyrido[2,3-b]naphthydrin-6(5H)-one were synthesized by a one-pot three-component condensation of 2,4-dihydroxyquinoline, 2-amino pyridine and various aromatic aldehydes with sulfamic acid as an enviro-economic catalyst. The salient features of this method consist of high atom economy and yields, short reaction time, non-carcinogenic solvents, and chromatography-free work-up procedure. Fascinatingly, the catalyst can be reused for up to four cycles giving good to excellent yields. By employing this method, a series of 14 pyrido[2,3-b]naphthydrin compounds were synthesized. This procedure is projected as a green avenue in the combinatorial synthesis of biologically active naphthydrin derivatives.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::77b6cbb2fa5982a0b0275464276a935a https://doi.org/10.1007/s11164-016-2778-2 Zobrazit plný text záznamu Full text from SpringerLink