A New Co(II)-Based Metal–Organic Framework for Size-Selective Cyanosilylation Reaction and Anti-cancer Activity Against Lung Cancer Cell via Inducing Apoptosis
| Autor: | Pei Sujuan, Huiling Li, Deng Zhijian, Xi Yuling, Zhenyun Li, Ru Yang, Fan Fangting |
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| Rok vydání: | 2019 |
| Předmět: |
Polymers and Plastics
Ligand Acetaldehyde 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Combinatorial chemistry 0104 chemical sciences Catalysis Metal Solvent Isophthalic acid chemistry.chemical_compound chemistry visual_art Materials Chemistry visual_art.visual_art_medium Metal-organic framework 0210 nano-technology Single crystal |
| Zdroj: | Journal of Inorganic and Organometallic Polymers and Materials. 30:2204-2212 |
| ISSN: | 1574-1451 1574-1443 |
| DOI: | 10.1007/s10904-019-01368-w |
| Popis: | A novel metal–organic framework {[Co4(HL)4](DMF)3}n (1, DMF = N,N-dimethylformamide) based on Co(II) ion as the metal source has been successfully prepared under the solvothermal condition using a mixed-donor pyridyl–tricarboxylate ligand 5-(5-carboxypyridin-3-yl)isophthalic acid (denoted as H3L). X-ray analysis of single crystal shows that they have a 3D PtS-type networks with non-interpenetrating (4,4)-connections, and the Schlafli point symbol is {42·84}. The resulting activated 1a has been explored in details for Brunauer–Emmett–Teller (BET) analysis to probe its porosity. It is commendable that the activated 1a can be applied as multiphase catalyst for cyanidation of acetaldehyde without solvent under the mild conditions. Furthermore, we aimed to evaluate the inhibitory function of compound on the anti-viability ability on of cancer cell, which was proved by the Cell Counting Kit-8 (CCK-8) test. To further detect the anti-cancer mechanism of the compound, the reverse transcription-polymerase chain reaction (RT-PCR) detection of the blc-2, bax relative expression in NCI-H460 was also measured. |
| Databáze: | OpenAIRE |
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