Adenovirus and RSV infections during pregnancy and their relationship to orofacial clefts
| Autor: | Elena Tichá, Mojmír Mach, Drahomír Palenčár, Eva Bieliková, Molnarova A, Dagmar Fekiačová |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0301 basic medicine Plant Science 01 natural sciences Biochemistry Virus 03 medical and health sciences Genetics Medicine Respiratory system Molecular Biology Ecology Evolution Behavior and Systematics Pregnancy biology business.industry Cell Biology medicine.disease RSV Infections Specific antibody 030104 developmental biology Immunology biology.protein Animal Science and Zoology Antibody business 010606 plant biology & botany |
| Zdroj: | Biologia. 75:1055-1061 |
| ISSN: | 1336-9563 0006-3088 |
| DOI: | 10.2478/s11756-019-00404-x |
| Popis: | This article reports the relationship between prenatal respiratory infections such as human respiratory adenovirus (HRAV) and/or human respiratory syncytial virus (HRSV) and orofacial clefts (OFC). Specific antibodies against HRAV and HRSV were investigated serologically (ELISA) in newborns with orofacial cleft and their mothers. The results were compared with those obtained from healthy newborns (controls) and their mothers. Statistical evaluation revealed significant changes in HRAV IgA antibodies between mothers of children with OFC and mothers with healthy newborns. HRSV antibodies of newborns with OFC were changed only marginaly (p = 0.0665) compared to controls. Our results indicate possible involvement of HRSV and HRAV in congenital orofacial defects, however these results have to be confirmed in larger scale study. |
| Databáze: | OpenAIRE |
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