Intrarectal Dehydroleucodine Suppresses Trinitrobenzene Sulfonic Acid–Induced Colitis in Rats, A Model for Inflammatory Bowel Disease
| Autor: | Oscar S. Giordano, A. O. M. María, Graciela Haydée Wendel, Lilian Eugenia Pelzer, Guzmán Ja, Nora S. Domínguez, Luis Scardapane, Fabian Mohamed |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Pharmaceutical Science Inflammation Sulfonic acid Gastroenterology Inflammatory bowel disease Dehydroleucodine Internal medicine Drug Discovery medicine Colitis Pharmacology chemistry.chemical_classification business.industry Histology General Medicine Enema medicine.disease digestive system diseases Diarrhea Complementary and alternative medicine chemistry Molecular Medicine medicine.symptom business |
| Zdroj: | Pharmaceutical Biology. 45:316-323 |
| ISSN: | 1744-5116 1388-0209 |
| Popis: | Dehydroleucodine (DhL), isolated from Artemisia douglasiana. Besser (Asteraceae), prevents damage in acetic acid–induced colitis in rats. The trinitrobenzene sulfonic acid (TNBS)-induced model of chronic inflammation of the rat colon was used to determine the efficacy of DhL, at dose of 40 mg/kg, administered in enema form. All rats were sacrificed on day 7 and the colon excised, weighed, and rated macroscopically. Sections of colon were processed for light microscopy. Macroscopic scoring showed a decrease (p < 0.001) in the degree of damage in the DhL group compared with the group of rats treated with TNBS. Colon mass decreased (p < 0.05) in the DhL group compared with the TNBS group. Treatment with DhL resulted in a reduction in the incidence of diarrhea. Light-microscopic examination revealed preservation of mucosal architecture in the DhL-treated rats. DhL had an effective healing capacity at both macroscopic and microscopic levels. We conclude that DhL decreases injury and/or promotes healing... |
| Databáze: | OpenAIRE |
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