The Secrets of Crypticity and its Relationship to Medical Problems: Autoimmune Disease, Transplantation and Cancer

Autor:	Eli E. Sercarz, Gilles Benichou, Vatsala Bhardwaj, Stephen P. Schoenberger
Rok vydání:	1992
Předmět:	Autoimmune disease Transplantation Tolerance induction T cell repertoire Antigen Immunology medicine Cancer Biology medicine.disease medicine.disease_cause Organism Autoimmunity
Zdroj:	Theoretical and Experimental Insights into Immunology ISBN: 9783642769795
DOI:	10.1007/978-3-642-76977-1_27
Popis:	The cryptic self represents those poorly presented antigenic determinants that exist within the organism, against which the T cell repertoire has not been rendered tolerant. Occasional availability of certain cryptic determinants may have a detrimental consequence and cause autoimmunity. On the other hand, cryptic determinants may be able to be harnessed to perform worthwhile tasks such as raising anti-tumor responsiveness.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::77a0b8ca0c498755ee0187f2ef5ffedc https://doi.org/10.1007/978-3-642-76977-1_27 Zobrazit plný text záznamu