Effects of platelet-activating factor on endothelial cells and fibroblasts in vitro
| Autor: | Tai-Ping D. Fan, Rachel L. Smither |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Tube formation
medicine.medical_specialty Endothelium Platelet-activating factor Angiogenesis Basic fibroblast growth factor Biology Endothelial stem cell chemistry.chemical_compound Vascular endothelial growth factor A Endocrinology medicine.anatomical_structure chemistry In vivo Internal medicine medicine Cancer research |
| Zdroj: | Experientia Supplementum ISBN: 9783034870030 |
| Popis: | Angiogenesis, the formation of new blood vessels, is normally under stringent control. Persistent angiogenesis can lead to pathological conditions such as atherosclerosis, diabetic retinopathy and rheumatoid arthritis. There are three major components of angiogenesis, namely protease production by endothelial cells (EC) and fibroblasts, migration and proliferation of EC, and EC tube formation. Recent studies, using both in vivo and in vitro models of angiogenesis, have established the role of several polypeptide growth factors in these processes [1]. Some, e.g. basic fibroblast growth factor, are involved in all three events, while others, e.g. transforming growth factor-β and tumour necrosis factor-α, are not. The role of small molecular weight inflammatory mediators, which are likely to be present at sites of tissue inflammation, is less well characterised. |
| Databáze: | OpenAIRE |
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