Synthesis of conjugates of closo-dodecaborate dianion with cholesterol using a 'click' reaction
| Autor: | Irina D. Kosenko, Anna A. Druzina, Olga B. Zhidkova |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
inorganic chemicals
010405 organic chemistry Chemistry Dodecaborate chemistry.chemical_element General Chemistry Tetrahydropyran 010402 general chemistry 01 natural sciences Medicinal chemistry Cycloaddition 0104 chemical sciences chemistry.chemical_compound Nucleophile Click chemistry Sodium azide Boron Derivative (chemistry) |
| Zdroj: | Russian Chemical Bulletin. 69:1080-1084 |
| ISSN: | 1573-9171 1066-5285 |
| Popis: | The nucleophilic ring-opening reaction of tetrahydropyran derivative of the closo-dode-caborate dianion with sodium azide in the presence of tetrabutylammonium bromide led to the novel azido-derivatives of[B12H12]2−. A Cu-catalyzed 1,3-dipolar [3+2] cycloaddition reaction of the closo-dodecaborate dianion azido-derivatives with alkynyl-cholesterol led to 1,4-disubstituted 1,2,3-triazoles with the closo-dodecaborate fragment at position 1. The resulting conjugates are potentially suitable for the development of liposomal drugs to selectively deliver boron into a tumor cell for boron neutron capture therapy of cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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