68 Ga-PSMA Positron Emission Tomography/Computerized Tomography for Primary Diagnosis of Prostate Cancer in Men with Contraindications to or Negative Multiparametric Magnetic Resonance Imaging: A Prospective Observational Study
| Autor: | Rodolfo Hurle, Giovanni Lughezzani, Silvia Zandegiacomo, Roberto Peschechera, Arturo Chiti, Alberto Saita, Piergiuseppe Colombo, Giuliana Lista, Nicolò Maria Buffi, Alessio Benetti, Davide Maffei, Luisa Pasini, Luca Balzarini, Katia Marzo, Massimo Lazzeri, Angelo Castello, Egesta Lopci, Paolo Casale, Giorgio Guazzoni, Pasquale Cardone |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Urology Magnetic resonance imaging Rectal examination medicine.disease 030218 nuclear medicine & medical imaging 03 medical and health sciences Prostate cancer 0302 clinical medicine medicine.anatomical_structure Prostate Positron emission tomography 030220 oncology & carcinogenesis Biopsy medicine Tomography Radiology business Multiparametric Magnetic Resonance Imaging |
| Zdroj: | Journal of Urology. 200:95-103 |
| ISSN: | 1527-3792 0022-5347 |
| DOI: | 10.1016/j.juro.2018.01.079 |
| Popis: | Purpose: 68Ga labeled prostate specific membrane antigen positron emission tomography/computerized tomography may represent the most promising imaging modality to identify and risk stratify prostate cancer in patients with contraindications to or negative multiparametric magnetic resonance imaging.Materials and Methods: In this prospective observational study we analyzed 68Ga labeled prostate specific membrane antigen positron emission tomography/computerized tomography in a select group of patients with persistently elevated prostate specific antigen and/or Prostate Health Index suspicious for prostate cancer, negative digital rectal examination and at least 1 negative biopsy. The cohort comprised men with equivocal multiparametric magnetic resonance imaging (Prostate Imaging-Reporting and Data System, version 2 score of 2 or less), or an absolute or relative contraindication to multiparametric magnetic resonance imaging. Sensitivity, specificity and CIs were calculated compared to histopathology finding... |
| Databáze: | OpenAIRE |
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