Discussion
| Autor: | E. Vázquez García, C. Miralles Alvarez, A. Oscampo Hermida, C. Martínez Vázquez, P. Diz Dios |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Cancer Research
biology business.industry Mucocutaneous zone virus diseases medicine.disease biology.organism_classification Immune system Oncology Acquired immunodeficiency syndrome (AIDS) Immunopathology Immunology Medicine Protease inhibitor (pharmacology) Ritonavir Sarcoma Oral Surgery business Sida medicine.drug |
| Zdroj: | Oral Oncology. 34:236-238 |
| ISSN: | 1368-8375 |
| DOI: | 10.1016/s1368-8375(97)00082-1 |
| Popis: | This paper describes a case report of an HIV-infected patient with mucocutaneous Kaposi's sarcoma (KS) with oral involvement, which presented complete clinical resolution of lesions on antiretroviral treatment with ritonavir, an HIV-1 protease inhibitor. Although it has still not been demonstrated that ritonavir has a specific antiviral action against HHV-8, a gamma herpesvirus probably involved in KS aetiopathogenesis, it has been proven that it reduces the HIV load significantly. This affects certain growth factors of KS, such as Tat protein and cytokines, and favours recovery of immune function, which correlates with protection against AIDS-defining conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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