Evaluation of the liver functional changes in modeling the hemodynamic effects of microgravity in bed rest studies
| Autor: | B. V. Afonin, A. A. Solovieva, G. A. Tikhonova, E. A. Sedova, Valuev Va |
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| Rok vydání: | 2016 |
| Předmět: |
Breath test
Diminution medicine.medical_specialty Pathology medicine.diagnostic_test Physiology business.industry medicine.medical_treatment Hemodynamics Abdominal cavity Blood flow Bed rest 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Physiology (medical) Internal medicine Detoxification medicine Cardiology business 030217 neurology & neurosurgery Hemodynamic effects |
| Zdroj: | Human Physiology. 42:747-751 |
| ISSN: | 1608-3164 0362-1197 |
| DOI: | 10.1134/s0362119716070021 |
| Popis: | Ultrasonic examinations of eight male volunteers during bed rest in the antiorthostatic position (ANOP) at–15° showed plethora in the venous system of the abdominal cavity and slow blood flow through the liver with no effect on biochemical parameters. The 13C-methcetine breath test (13C-MBT) with 100 mg of 13C-methoxymethacetine showed diminution of the metabolic capacity and decline in the rate of detoxification activity of the liver due to functional changes related to hemodynamic alterations in ANOP. 13C-MBT can be used as a noninvasive method for diagnosing functional changes in the liver induced by hemodynamic reorganization in microgravity and other states triggering similar hemodynamic mechanisms. |
| Databáze: | OpenAIRE |
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