Pd-Catalyzed Carboetherification of β,γ-Unsaturated Oximes: A Novel Approach to Δ2-Isoxazolines

Autor:	Jinsong Peng, Yuanwei Chen, Dahong Jiang
Rok vydání:	2008
Předmět:	chemistry.chemical_compound Chemistry Ligand Xantphos Aryl Organic Chemistry Organic chemistry Physical and Theoretical Chemistry Beta (finance) Biochemistry Catalysis
Zdroj:	Organic Letters. 10:1695-1698
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol8002173
Popis:	A novel route to the synthesis of Δ2-isoxazoline derivatives is described. Reaction of β,γ-unsaturated oximes with aryl bromides via palladium-catalyzed carboetherification affords 3,5-disubstituted Δ2-isoxazolines in good yields. The use of Xantphos as ligand is crucial for the transformation. The carboetherification products can be further converted to β-hydroxy ketones in the presence of Fe powder and NH4Cl.
Databáze:	OpenAIRE
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